Posted 50 minutes ago


Researchers eliminate HIV from cultured human cells for first time

HIV-1, the most common type of the virus that causes AIDS,has proved to be tenacious, inserting its genome permanently into its victims’ DNA, forcing patients to take a lifelong drug regimen to control the virus and prevent a fresh attack. Now, a team of Temple University School of Medicine researchers has designed a way to snip out the integrated HIV-1 genes for good.

"This is one important step on the path toward a permanent cure for AIDS," says Kamel Khalili, PhD, Professor and Chair of the Department of Neuroscience at Temple. Khalili and his colleague, Wenhui Hu, MD, PhD, Associate Professor of Neuroscience at Temple, led the work which marks the first successful attempt to eliminate latent HIV-1 virus from human cells. "It’s an exciting discovery, but it’s not yet ready to go into the clinic. It’s a proof of concept that we’re moving in the right direction," added Dr. Khalili, who is also Director of the Center for Neurovirology and Director of the Comprehensive NeuroAIDS Center at Temple.

In a study published July 21 by theProceedings of the National Academy of Sciences, Khalili and colleagues detail how they created molecular tools to delete the HIV-1 proviral DNA. When deployed, a combination of a DNA-snipping enzyme called a nuclease and a targeting strand of RNA called a guide RNA (gRNA) hunt down the viral genome and excise the HIV-1 DNA. From there, the cell’s gene repair machinery takes over, soldering the loose ends of the genome back together — resulting in virus-free cells.

"Since HIV-1 is never cleared by the immune system, removal of the virus is required in order to cure the disease," says Khalili, whose research focuses on the neuropathogenesis of viral infections. The same technique could theoretically be used against a variety of viruses, he says.

Posted 1 hour ago



Gumdrops, chocolates, cookies, ice cream and stuff.


Posted 1 hour ago





hmmm i wonder what they used to take these pretentious fucking pictures if technology is so evil, jesus christ

You don’t need a phone to take photos. It’s called a camera.


(Source: nevver)

Posted 1 hour ago



A review for Skyrim, just look at those hours.

Holy shit. Us schlubs with 1500 hours be kiddy grade.

Posted 1 hour ago


fleur delacour is so important i can’t even put it into words

badass girl whose “most precious” was her sister, who despite what anyone might think of her (cough molly cough ron cough hermione cough) looks past any aesthetic unpleasantries because she is completely and…

(Source: hrodens)

Posted 2 hours ago



And in the words of the most appropriate tumblr trend
“I came out tonight to have a good time and I feel so attacked right now.”

this actually describes tumblr perfectly

Posted 2 hours ago





British Rowing Team Poses Naked to Help Fight Homophobia

How exactly does this fight homophobia really

shh the pretty boys are naked for justice

i like justice

Posted 2 hours ago

no image has ever described my life quite so well


no image has ever described my life quite so well

Posted 2 hours ago


I absolutely love her. She is honest and just herself always

(Source: robotmayo)

Posted 2 hours ago

Natalie Dormer on Women and Body Image in Hollywood during SDCC 2014 (x)

(Source: rubyredwisp)

Posted 2 hours ago
Posted 2 hours ago

Lara Croft and Nathan Drake

(Source: ask-lara-croft-blog)

Posted 2 hours ago

Hey guys I had a bunch of links to books so I thought i would share them, Enjoy!

Harry Potter And The Sorcerers Stone (x)
Harry Potter And The Chamber Of Secrets (x)
Harry Potter And The Prisoner Of Azkaban (x)
Harry Potter And The Goblet Of Fire (x)
Harry Potter And The Order Of The Phoenix (x)
Harry Potter And The Half Blood Prince (x)
Harry Potter And The Deathly Hollows (x)
Fantastic Beasts and Where to Find Them (x)
Hunger Games Suzanne Collins(x)
Catching Fire Suzanne Collins (x)
Mocking Jay Suzanne Collins (x)
The Mortal Instruments:
City of Bones Cassandra Clare (x)
City of Ash Cassandra Clare(x)
City of Glass Cassandra Clare (x)
City of Fallen Angels Cassandra Clare (x)
City of Lost Souls Cassandra Clare(x)
The Infernal Devices:
Clockwork Angel Cassandra Clare(x)
Clockwork Prince Cassandra Clare (x)
Clockwork Princess Cassandra Clare(x)
Percy Jackson and the Lightning Thief Rick Riordan (x)
Percy Jackson and the Sea of Monsters Rick Riordan (x)
Percy Jackson and the Titan’s Curse Rick Riordan (x)
Percy Jackson and the Battle of the Labyrinth Rick Riordan (x)
Percy Jackson and the The Last Olympian Rick Riordan (x)
The Demigod Files Rick Riordan (x)
The Lost Hero Rick Riordan (x)
The Son of Neptune Rick Riordan (x)
The Mark of Athena Rick Riordan (x)
House of Hades Rick Riordan (x)
The Demigod Diaries Rick Riordan (x)
Vampire Academy by Richelle Mead (x)
Vampire Academy: Frostbite by Richelle Mead(x)
Vampire Academy: Shadow Kiss by Richelle Mead (x)
Vampire Academy: Blood Promise by Richelle Mead (x)
Vampire Academy: Spirit Bound by Richelle Mead (x)
Vampire Academy: Last Sacrifice by Richelle Mead (x)
A Game of Thrones by George RR Martin (x)
A Clash of Kings by George RR Martin (x)
A Storm of Swords by George RR Martin (x)
A Feast of Crows by George RR Martin (x)
A Dance with Dragons by George RR Martin (x)
The Hobbit J. R. R. Tolkien (x)
Lord of the Rings: The Fellowship of the Ring J. R. R. Tolkien (x)
Lord of the Rings: The Two Towers  J. R. R. Tolkien (x)
Lord of the Rings: The Return of the King J. R. R. Tolkien (x)
Silmarillion by J.R.R Tolkien (x)
12 volumes of the History of Middle Earth (x)
The Children of Húrin (x)
Divergent by Veronica Roth (x)
Insurgent by Veronica Roth (x)
Allegiant by Veronica Roth (x)
The Maze Runner by James Dashner (x)
The Scorch Trials by James Dashner (x)
The Death Cure by James Dashner (x)
Prequel The Kill Order by James Dashner (x)
The Chronicles Of Narnia:
The Lion, the Witch and the Wardrobe by C.S Lewis (x)
Prince Caspian: The Return to Narnia by C.S Lewis (x)
The Voyage of the Dawn Treader by C.S Lewis (x)
The Silver Chair by C.S Lewis (x)
The Horse and His Boy by C.S Lewis (x)
The Magician’s Nephew by C.S Lewis audio book (x)
The Last Battle by C.S Lewis (x)
The Prince by Kiera Cass  (x)
The Selection by Kiera Cass (x)
The Elite by Kiera Cass (x)
The Guard by Kiera Cass (x)
Matched by Ally Condie (x)
Crossed by Ally Condie (x
Reached by Ally Condie (x)
Annabel Delirium 0.5 by Lauren Oliver (x)
Delirium by Lauren Oliver (x)
Hana Delirium 1.5 by Lauren Oliver (x)
Pandemonium by Lauren Oliver (x)
Raven Delirium 2.5 by Lauren Oliver (x)
Requiem by Lauren Oliver (x)
Uglies by Scott Westerfeld (x)
Pretties Scott Westerfeld (x)
Specials by Scott Westerfeld (x)
Extra’s by Scott Westerfeld (x)
The Giver by Lois Lowry (x)
Gathering Blue by Lois Lowry (x)
The Messenger by Lois Lowry (x)
Son by Lois Lowry (x)
Casual Vacancy by J.K. Rowling (x)
The Fault in our Stars John Green(x)
An Abundance of Katherine John Green (x)
Paper Towns John Green (x)
Looking for Alaska by John Green (x)
The Stand by Stephan King (x)
It by Stephen King (x)
The Shining by Stephen King (x)
The Tommyknockers by Stephen King (x)
Firestarter by Stephen King (x)
The Spectacular Now by Tim Tharp (x)
Jellicoe Road by Melina Marchetta (x)
Panic by Lauren Oliver (x)
Speak by Laurie Halse Anderson (x)
Stolen by Lucy Christopher (x)
Everyday by David Levithan (x)
If I Stay by Gayle Formam (x)
Nineteen Minutes by Jodi Picoul (x)
It’s Kind of a Funny Story by Ned Vizzini (x)
Along for the Ride Sarah Dessen (x)
Perks of Being a Wallflower Stephen Chbosky (x)
The Book Thief by Markus Zusak (x)
The Host by Stephanie Meyer (x)
1984 by George Orwell (x)
Animal Farm by George Orwell (x)
The Handmaid’s Tale by Margaret Atwood (x)
The Road by Cormac Mccarthy (x)
Fahrenheit 451  by Ray Bradbury (x)
Brave New World by Aldous Huxley (x)
The Pact by Jodi Picoult (x)
Thirteen Reasons Why by Jay Asher (x)
Truth About Forever by Sarah Dessen (x)
Warm Bodies by Isaac Marion (x)
White Oleander Janet Fitch (x)
Message in a Bottle by Nicholas Sparks (x)
Safe Haven by Nicholas Sparks (x)
Nora Roberts Chasing Fire (x)
Dare to Love Jaci Burton (x)
Miss Peregrine’s Home for Peculiar Children by Ransom Riggs (x)

(Source: themindreadingmutant)

Posted 2 hours ago


I have never reblogged anything faster in my life.

(Source: l0ve-pride-deepfried-chicken)

Posted 2 hours ago


Hannibal: the Musical at SDCC